A young neurosurgeon inherits the castle of his grandfather, the famous Dr. Victor von Frankenstein. In the castle he finds a funny hunchback, a pretty lab assistant and the elderly housekeeper. Young Frankenstein believes that the work of his grandfather was delusional, but when he discovers the book where the mad doctor described his reanimation experiment, he suddenly changes his mind.

To regain his strength, Dracula, the king of vampires, has returned to his native soil and his castle in the Carpathian Mountains. While there, he seeks a new bride to do his bidding and chooses a farmer’s daughter pure of heart. However, Dr. Victoria Frankenstein has other plans for the infected blood of Dracula’s new bride. Victoria plans to rejuvenate the Monster created by her grandfather, Henry Frankenstein, by mixing the vampire’s blood with the blood coursing through the Monster’s veins. Once Dracula learns of this treachery, he sets out to take his revenge!
– Written by Joe DeMuro

The hero, Hyakkimaru is a wandering “demon hunter” whose extra body parts — 48 to be exact — were grafted onto his head and trunk by a herb doctor who discovered him as an infant, in a process that echoes “Frankenstein” and “The Island of Dr. Moreau.” His warlord father gave the originals to 48 demons in exchange for power. When Hyakkimaru kills a demon, he wins back a body part. He is spotted in one of these battles, with a giant spider demon, by Dororo, a scrappy female thief who is fascinated by not only Hyakkimaru’s prowess with the sword blade poking out of his arm but the new leg he grows after dicing his opponent. Is he a man — or a monster? After hearing his story from an old minstrel, she decides to join him on his travels and find out for herself.